Title:expression of Histone Deacetylases 1,2 and 3 in Urothelial Bladder Cancer
نویسندگان
چکیده
Cédric Poyet ([email protected]) Bastian Jentsch ([email protected]) Thomas Hermanns ([email protected]) Daniel Schweckendiek ([email protected]) Hans-Helge Seifert ([email protected]) Martin Schmidtpeter ([email protected]) Tullio Sulser ([email protected]) Holger Moch ([email protected]) Peter J Wild ([email protected]) Glen Kristiansen ([email protected])
منابع مشابه
Expression of histone deacetylases 1, 2 and 3 in urothelial bladder cancer
BACKGROUND Histone deacetylases (HDACs) are known to be associated with an overexpression in different types of cancer such as colon and prostate cancer. In this study we aimed to evaluate the protein expression of class I HDACs in urothelial carcinoma of the bladder. METHODS A tissue microarray containing 348 tissuesamples from 174 patients with a primary urothelial carcinoma of the bladder ...
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Background: The aberrant and altered patterns of gene expression play an important role in the biology of cancer and tumorigenesis. DNA methylation and histone deacetylation are the most studied epigenetic mechanisms. Histone deacetylase inhibitors (HDACIs) such as valproic acid (VPA) and trichostatin A (TSA) are a group of anticancer compounds for the treatment of solid and hematological canc...
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Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. ...
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